Melizer is dedicated to the independent development and manufacturing of tissue-specific single-cell dissociation enzymes, with a clear mission: to convert complex tissues into high-viability, high-integrity single-cell suspensions in a precise and controlled manner.
Rather than relying on one-size-fits-all formulations, Melizer offers tailored multi-enzyme solutions optimized for different tissue types, including tumors, heart, liver, lung, spleen, brain, and other structurally challenging or fibrotic tissues. This design philosophy ensures minimal cellular damage, high cell yield, and excellent preservation of surface antigens and transcriptomic integrity.
EnzyRazer products are broadly compatible with downstream applications such as single-cell sequencing (scRNA-seq, scATAC-seq, snRNA-seq), flow cytometry and cell sorting, organoid research, primary cell culture, and cell and gene therapy workflows. By combining robust performance with strong cost efficiency, EnzyRazer significantly reduces experimental variability and breaks long-standing dependence on imported enzyme brands.
From fundamental research to translational and clinical applications, EnzyRazer is building a scalable product and service ecosystem spanning research-grade, industrial-grade, and future GMP-grade solutions—turning single-cell preparation from a fragile art into a reproducible, standardized, and trustworthy foundation for modern life science research.
Key Advantages
1. One-Step, Ready-to-Use Format
The enzyme is supplied as a lyophilized powder and requires only dissolution in the provided solvent to be ready for use.
Unlike peer products that require separate dissolution, volume calculation, and mixing of multiple enzymes, eliminates weighing, calculations, and complex preparation steps—significantly reducing operational errors.
2. Multi-Component Composite Enzyme System
Melizer product is an independently developed and manufactured composite enzyme, containing more than eight complementary enzymes optimized for cardiac extracellular matrix composition.
Compared with single collagenase IV, DNase, or 3–4 enzyme mixtures used by imported products, MJ001 delivers:
- Higher dissociation efficiency
- Shorter digestion time
- Higher cell yield
- Stronger cell viability
- Better preservation of surface antigens
In addition, in-house production ensures lower cost and stronger market competitiveness.
3. Rapid Dissociation
Thanks to its highly specific enzyme composition, most tissues can be fully dissociated within 10–15 minutes.
In contrast, traditional collagenase-based or imported enzyme mixtures typically require 1–3 hours to achieve comparable dissociation.
4. High Cell Yield
The multi-enzyme system enables more complete digestion of diverse extracellular matrix components, resulting in:
- Minimal residual tissue clumps
- More complete release of single cells
- Significantly improved cell recovery
5. High Cell Viability
Melizer provides tissue-specific enzymatic digestion that is gentler than trypsin and significantly reduces cellular damage.
Shorter digestion time minimizes ex vivo stress and prevents over-digestion, resulting in highly viable single cells with intact morphology.
6. Excellent Preservation of Surface Antigens
Reduced digestion time and minimal cellular damage lead to:
- Better structural integrity
- Higher cell viability
- Superior preservation of antigen epitopes
This makes Melizer’s product-processed cells particularly suitable for antibody staining, flow cytometry analysis, and cell sorting.